Researchers have discovered a brain mechanism that limits the rewarding sensations of cocaine. Recent research with rodents implicated histone deacetylases (HDACs), which are modulators of gene expression, in the regulation of cocaine-induced behaviors. However, the mechanism of this regualtion and whether it could modify addiction-related behaviors was unknown. Using a rodent model, the researchers discovered that cocaine triggered a novel signaling pathway that causes HDAC5 to move to the...
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